〜論文・総説のリスト〜
Publications (since 2011-)

太字表記の論文は解説付きページにリンクします。

Murata, T., Mizushima, H., Chinen, I., Moribe, H., Yagi, S., Hoffman, R.M., Kimura, T., Yoshino, K., Ueda, Y., Enomoto, T. and Mekada, E. (2011) 
HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers. 
Cancer Res. 71, 6633-6664.PickOutArticles/entori/2011/9/2_HB-EGFtoPDGFniyoru_ai_ai_jian_zhi_xiang_hu_zuo_yongwo_mingrakanisuru.html
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22009535

Koshikawa, N., Mizushima, H., Minegishi, T., Eguchi, F., Yotsumoto, F., Nabeshima, K., Miyamoto, S., Mekada, E., and Seiki, M.  (2011).

Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metlloproteinase-1 in ovarian carcinoma cells.

Cancer Sci. 102, 111-116.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20946474

Miyamoto, S., Iwamoto, R., Furuya, A., Takahashi, K., Sasaki, Y., Ando, H., Yotsumoto, F., Yoneda, T., Hamaoka, M., Yagi, H., Murakami, T., Hori, S., Shitara, K. and Mekada, E. (2011).


A novel anti-human HB-EGF monoclonal antibody with multiple anti-tumor mechanisms against ovarian cancer cells.

Clinical Cancer Res. 17, 6733-6741.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/21918176

Masuda H, Nakamura K, Takata N, Itoh B, Hirose T, Moribe H, Mekada E, Okada M. (2012)

MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.

FEBS Lett. 586, 740-746.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22293500

Takemura, T., YoshidaY., Kiso, S., Saji, Y., Ezaki, H., Hamano, M., Kizu, T., Egawa, M.,  Chatani, N., Furuta, K., Kamada, Y., Iwamoto, R., Mekada, E., Higashiyama, S., Hayashi, N. and Takehara, T. (2012)

Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice. 

Hepatol Res. 43, 384-393.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22882498

Nishikawa K, Asai T, Shigematsu H, Minamino T, Asano Y, Takashima S, Mekada E, Oku N. (2012)

Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.

J Control Release. 160, 274-280.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/22020380
Moribe, H., Konakawa, R., Yoneda, T., Koga, D., Ushiki, T., Nakamura K. and Mekada, E. (2012)
Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. 
PLoS Genet. 8(9):e1002957.
PickOutArticles/entori/2012/10/12_tetorasupaningadual_oxidaseniyoru_huo_xing_suan_suno_chan_sheng_jing_luni_bi_yaona_yin_zidearukotowo_zheng_mingsuru.html
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23028364

Kasai N, Kobayashi K, Shioya S, Yoshikawa Y, Yotsumoto F, Miyamoto S, Mekada E, Enokizono J. (2012)

Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer.

Am J Transl Res. 4, 415-421.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23145209

Nam, S. O., Yotsumoto, F., Miyata, K., Suzaki, Y., Yagi, H., Odawara, T., Manabe, S., Ishikawa, T., Kuroki, M., Mekada, E. and Miyamoto, S. (2014) Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy. Anticancer Res. 34, 4615-4620.

Iwamoto, R., Takagi, M., Akatsuka, J. I., Ono, K. I., Kish, Y. and Mekada, E. (2016) Characterization of a novel anti-human HB-EGF monoclonal antibody applicable for paraffin-embedded tissues and diagnosis of HB-EGF-related cancers. Monoclon. Antib. Immunodiagn. Immunother. 35, 73-82.

Murata, T., Mekada, E. and Hoffman, R.M. (2017) Reconstitution of a metastatic-resistant tumor microenvironment with cancer-associated fibroblasts enables metastasis. Cell Cycle. 16(6): 533-535.

Miyamoto, S., Yotsumoto, F., Ueda, T., Fukami, T., Sanui, A., Miyata, K., Ouk Nam, S., Fukagawa, S., Katsuta, T., Maehara, M., Kondo, H., Miyahara, D., Shirota, K., Yoshizato, T., Kuroki, M., Nishikawa, H., Saku, K., Tsuboi, Y., Ishitsuka, K., Takamatsu, Y., Tamura, K., Matsunaga, A., Hachisuga, T., Nishino, S., Odawara, T., Maeda, K., Manabe, S., Ishikawa, T., Okuno, Y., Ohishi, M., Hikita, T., Mizushima, H., Iwamoto, R. and Mekada, E. (2017) BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: A first-in-human phase-I studyBMC Cancer. 17(1): 89.

Iwamoto, R., Mine, N., Mizushima, H. and Mekada, E. (2017) ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis. J. Cell Sci. 130(7): 1321-1332.

Moribe, H., Mekada, E. (2013) Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes. Worm. 2(2), e23415.

Odintsova, E., van Nie, G., Conjeaud, H., Raposo, G., Iwamoto, R., Mekada, E., and Berditchevski, F. (2013) Metastasis suppressor tetraspanin CD82/KAI1 regulates ubiquitylation of epidermal growth factor receptor. J. Biol. Chem. 288, 26323-26334.

Takemura, T., Yoshida, Y., Kiso, S., Kizu, T., Furuta, K., Ezaki, H., Hamano, M., Egawa, M., Chatani, N., Kamada, Y., Imai, Y., Higashiyama, S., Iwamoto, R., Mekada, E. and Takehara, T. (2013) Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. Biochem. Biophys. Res. Commun. 437, 185-191.

Okamoto, A., Asai, T., Kato, H., Ando, H., Minamino, T., Mekada, E. and Oku, N. (2014) Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF. Biochem. Biophys. Res. Commun. 449, 460-465.

Suzuki, K., Mizushima, H., Abe, H., Iwamoto, R., Nakamura, H. and Mekada, E. (2015) Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.  J. Biochem. 157, 331-343.

PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/24058871
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/23897813
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/23743191
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/25075108
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/24853808
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/25432160
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/26974561
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/28103135
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/28143428
PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/28232522