〜論文・総説のリスト〜
Publications (2000-2010)

Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., and Mekada, E. (2006).

Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor.

Cell Struct. Funct. 31, 15-27.

Iwamoto, R. and Mekada, E. (2006).

ErbB and HB-EGF signaling in heart development and function.

Cell Struct. Funct. 31, 1-14. Review.

Kimura, R., Iwamoto, R., and Mekada, E. (2005).

Soluble form of heparin-binding EGF-like growth factor contributes to retinoic acid-induced epidermal hyperplasia.

Cell Struct. Funct. 30, 35-42.

Mine, N., Iwamoto, R., and Mekada, E. (2005).
HB-EGF promotes epithelial cell migration in eyelid development.
Development 132, 4317-4326.PickOutArticles/entori/2005/9/1_HB-EGFgamausuno_mu_gai_xing_chengni_guan_yushiteirukotowo_mingrakanisuru.html

Tanaka, Y., Miyamoto, S., Suzuki, S. O., Oki, E., Yagi, H., Sonoda, K., Yamazaki,A., Mizushima, H., Maehara, Y., Mekada, E., and Nakano,H. (2005).

Clinical Significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.

Clin. Cancer Res.11, 4783-4792.

Shirakata, Y., Kimura, K., Nanba, D., Iwamoto, R., Tokumaru, S., Morimoto, C., Yokota, K., Nakamura, M., Sayama, K., Mekada, E., Higashiyama, S., and Hashimoto, K. (2005).

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.

J. Cell Sci. 118, 2363-2370

Yagi, H., Miyamoto, S., Tanaka, Y., Sonoda, K., Kobayashi, H., Kishikawa, T., Iwamoto, R., Mekada, E., and Nakano, H. (2005).

Clinical significance of heparin-binding epidermal growth factor-Like growth factor in peritoneal fluid of ovrain cancer.

Brit. J. Cancer. 92, 1737-1745.

Katayama, H., Yokota, H., Akao, T., Nakamura, O., Ohba, O., Mekada, E., and Mizuki, E. (2005).

Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis.

J. Biochem. 137, 17-25.

Takazaki, R., Shishido, Y., Iwamoto, R., and Mekada, E. (2004).
Suppression of the biological activities of the EGF-like domain by the heparin-binding domain of heparin-binding EGF-like growth factor.
J. Biol. Chem. 279, 47335-47343. PickOutArticles/entori/2004/11/5_HB-EGFnoheparin_jie_he_ling_yugaHB-EGFno_sheng_li_huo_xingwo_funi_zhi_yushiteirukotowo_mingrakanishita.html
Moribe, H., Yochem, J., Yamada, H., Tabuse, Y., Fujimoto, T., and Mekada, E. (2004).
Requirement for TSP-15, a tetraspanin protein, for epidermal integrity in Caenorhabditis elegans.
J. Cell Sci. 117, 5209-5220.PickOutArticles/entori/2004/10/15_tetorasupaninga_shang_pino_gou_zhuni_bi_xudearukotowo_mingrakanisuru.html
Miyamoto, S., Hirata, M., Yamazaki, A., Kageyama, T., Hasuwa, H., Mizushima, H., Tanaka, Y., Yagi, H., Sonoda, K., Kai, M., Kanoh, H., Nakano, H., and Mekada, E. (2004).
Heparin-binding EGF-like growth factor and the LPA-induced ectodomain shedding pathway is a promising target for the therapy of ovarian cancer. 
Cancer Res. 64, 5720-5727. PickOutArticles/entori/2004/8/15_HB-EGFga_luan_chao_ai_zhi_liaono_you_wangna_biao_dedearukotowo_mingrakanishita.html

Ishibashi, T., Ding, L., Ikenaka, K., Inoue, Y., Miyado, K., Mekada, E., and Baba, H. (2004).

Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation.

J. Neurosci. 24, 96-102.

Yamazaki, S., Iwamoto, R., Saeki, K., Asakura, M., Takashima, S., Yamazaki, A., Kimura, R., Mizushima, H., Moribe, H., Higashiyama, S., Endoh, M., Kaneda, Y., Takagi, S., Itami, S., Takeda, N., Yamada, G., and Mekada. E. (2003).
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.
J. Cell Biol. 163, 469-475. PickOutArticles/entori/2003/11/10_HB-EGFno_qie_duan_guo_chengno_yan_mina_zhi_yugamausuno_zheng_changna_fa_shengni_bi_xudearukotowo_mingrakanisuru.html
Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., Nanba, D., Higashiyama, S., Hori, M., Klagsbrun, M., and Mekada, E. (2003).
HB-EGF and ErbB signaling is essential for heart function.
Proc. Natl. Acad. Sci. USA 100, 3221-3226.PickOutArticles/entori/2003/3/18_HB-EGFga_zheng_changna_xin_zang_xing_chengto_ji_neng_wei_chini_bi_xudearukotowo_mingrakanisuru.html

Takenobu, H., Yamazaki, A., Hirata, M., Umata, T., and Mekada, E. (2003).

The stress- and the inflammatory cytokine-induced ectodomain shedding of heparin-binding EGF-like growth factor is mediated by p38 MAPK, distinct from TPA-induced and LPA-induced signaling cascades.

J. Biol. Chem. 278, 17255-17262.

Takeda, Y., Tachibana, I., Miyado, K., Kobayashi, M., Miyazaki, T., Funakoshi, T., Kimura, H., Yamane, H., Saito, Y., Goto, H., Yoneda, T., Yoshida, M., Kumagai, T., Osaki, T., Hayashi, S., Kawase, I., and Mekada, E. (2003).

Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.

J. Cell Biol. 161, 945-956.

Yu, X., Sharma, K. D., Takahashi, T., Iwamoto, R., and Mekada, E. (2002).

Ligand-independent dimer formation of EGFR is a step separable from ligand-induced EGFR signaling.

Mol. Biol. Cell 13, 2547-2457.

Shimizu, T., Matsuishi, T., Iwamoto, R., Handa, K., Yoshioka, H., Kato, H., Ueda, S., Hara, H., Tabira, T., and Mekada, E. (2002).

Elevated cerebrospinal fluid levels of anti-CD9 antibodies in patients with subacute sclerosing panencephalitis.

J. Infect. Dis. 185, 1346-1350.

Kawashima, M., Doh-ura, K., Mekada, E., Fukui, M., and Iwaki, T. (2002).

CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors.

J. Histochem. Cytochem. 50, 1195-1203.

Umata, T., Hirata, M., Takahashi, T., Ryu, F., Shida, S., Takahashi, Y., Tsuneoka, M., Miura, Y., Masuda, M., Horiguchi, Y., and Mekada, E. (2001).

A dual signaling cascade that regulates the ectodomain shedding of HB-EGF.

J. Biol. Chem. 276, 30475-30482.

Hirata, M., Umata, T., Takahashi, T., Ohnuma, M., Miura, Y., Iwamoto R., and Mekada, E. (2001).

Identification of serum factor inducing ectodomain shedding of proHB-EGF and studies of non-cleavable mutants of proHB-EGF.

Biochem. Biophys. Res. Commun. 282, 915-922.

Hasuwa, H., Shishido, Y., Yamazaki, A., Kobayashi, T., Yu, X., and Mekada, E. (2001).

CD9 amino acids critical for upregulation of diphtheria toxin binding.

Biochem. Biophys. Res. Commun. 289, 782-790.

Takahashi, T., Umata, T., and Mekada, E. (2001).

Extension of juxtamembrane domain of diphtheria toxin receptor arrests translocation of diphtheria toxin fragment A into cytosol.

Biochem. Biophys. Res. Commun. 281, 690-696.

Nakamura, Y., Handa, K., Iwamoto, R., Tsukamoto, T., Takahashi, M., and Mekada, E. (2001).

Immunohistochemical distribution of CD9, heparin binding epidermal growth factor-like growth factor and integrin a3b1 in normal human tissues.

J. Histochem. Cytochem. 49, 439-444.

Miyamoto, S., Maruyama, A., Okugawa, K., Akazawa, K., Baba, H., Maehara, Y., and Mekada, E. (2001).

Loss of motility-related protein 1 (MRP1/CD9) and integrin alpha3 expression in endometrial cancers.

Cancer 92, 542-548.

Kusukawa, J., Ryu, F., Kameyama, T., and Mekada, E. (2001).

Reduced expression of CD9 in oral squamous cell carcinoma: CD9 expression inversely related to high prevalence of lymph node metastasis.

J. Oral Pathol. Med. 30, 73-79.

Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Munehiro, N., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., and Kohno, K. (2001).

Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice.

Nat. Biotechnol. 19, 746-750.

Miyado, K., Yamada, G., Yamada, S., Hasuwa, H., Nakamura, Y., Ryu, F., Suzuki, K., Kosai, K., Inoue, K., Ogura, A., Okabe, M., and Mekada, E. (2000).

Requirement of CD9 on the egg plasma membrane for fertilization.

Science 287, 321-324.

Nakamura, K., Mitamura, T., Takahashi, T., Kobayashi, T., and Mekada, E. (2000).

Importance of the Major Extracellular Domain of CD9 and the EGF-like Domain of HB-EGF for Upregulation of Binding and Activity.

J. Biol. Chem. 275, 18284-18290.

Tsuneoka, M. and Mekada, E. (2000).

Ras/MEK signaling suppresses Myc-dependent apoptosis in cells transformed by c-myc and activated ras.

Oncogene 19, 115-123.

Baba, I., Shirasawa, S., Iwamoto, R., Okumura, K., Tsunoda, T., Nishioka, M., Fukuyama, K., Yamamoto, K., Mekada, E., and Sasazuki, T. (2000).

Involvement of deregulated epiregulin expression in tumorigenesis in vivo through activated Ki-Ras signaling pathway in human colon cancer cells.

Cancer Res. 60, 6886-6889.

Saeki, K., Suzuki, H., Tsuneoka, M., Maeda, M., Iwamoto, R., Hasuwa, H., Shida, S., Takahashi, T., Sakaguchi, M., Endo, T., Miura, Y., Mekada, E., and Mihara, K. (2000).

Identification of mammalian Tom22 as a subunit of the preprotein translocase of the mitochondrial outer membrane.

J. Biol. Chem. 275, 31996-32002.

Suzuki, H., Okazawa, Y., Komiya, T., Saeki, K., Mekada, E., Kitada, S., Ito, A., and Mihara, K. (2000).

Characterization of Rat Tom40, a central component of the preprotein translocase of the mitochondrial outer membrane.

J. Biol. Chem. 275, 37930-37936.

Doh-ura, K., Mekada, E., and Iwaki, T. (2000).

Enhanced CD9 expression in the human and mouse brains infected with transmissible spongiform encephalopathies.

J. Neuropathol. Exp. Neurol. 59, 774-785.

Ryu, F., Takahashi, T., Nakamura, K., Takahashi, Y., Kobayashi, T., Shida, S., Kameyama, T., and Mekada, E. (2000).

Domain analysis of the tetraspanins: studies of CD9/CD63 chimeric molecules on subcellular localization and upregulation activity for diphtheria toxin binding.

Cell Struct. Funct. 25, 317-327.

Iwamoto, R. and Mekada E. (2000).

Heparin-binding EGF-like growth factor: a juxtacrine growth factor.

Cytokine & Growth Factor Reviews 11, 335-344.

Kakumoto, K., Sasaki, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., and Akagi, T. (2006).

FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.

Proc. Natl. Acad. Sci. USA. 103, 5490-5495.

Miyamoto, S., Yagi, H., Yotsumoto, F., Kawarabayashi, T., and Mekada, E. (2006).

Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy.

Cancer Sci. 97, 341-347. Review.

Nanba, D., Kinugasa, Y., Morimoto, C., Koizumi, M., Yamamura, H., Takahashi, K., Takakura, N., Mekada, E., Hashimoto, K., and Higashiyama, S. (2006).

Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.

Biochem. Biophys. Res. Commun. 350, 315-321.

Katayama, H., Kusaka, Y., Yokota, H., Akao, T., Kojima, M., Nakamura, O., Mekada, E., and Mizuki, E. (2007).

Parasporin-1, a Novel Cytotoxic Protein from Bacillus thuringiensis, Induces Ca2+ Influx and a Sustained Elevation of the Cytoplasmic Ca2+ Concentration in Toxin-sensitive Cells.

J. Biol. Chem. 282, 7742-7752.

Tanigawa, M., Miyamoto, K., Kobayashi, S., Sato, M., Akutsu, H., Okabe, M., Mekada, E., Sakakibara, K., Miyado, M., Umezawa, A., and Miyado, K. (2007).

Possible involvement of CD81 in acrosome reaction of sperm in mice.

Mol. Reprod. Dev. 75, 150-155.

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Kageyama, T., Ohishi, M., Miyamoto, S., Iwamoto, R. and Mekada, E. (2007).

Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.

J. Biochem. 142, 95-104.

Sonoda, K., Miyamoto, S., Yamazaki, A., Kobayashi, H., Nakashima, M., Mekada, E., and Wake, N. (2007).

Biologic significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) as a pivotal regulator of tumor growth through angiogenesis in human uterine cancer

Cancer 110, 1979-1990.

Xie, H., Wang, H., Tranguch, S., Iwamoto, R., Mekada, E., Demayo, F. J., Lydon, J. P., Das, S. K. and Dey, S. K. (2007).

Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.

Proc. Natl. Acad. Sci. USA. 104, 18315-18320.

Oki, S., Hashimoto, R., Okui, Y., Shen, M. M., Mekada, E., Otani, H., Saijoh, Y. and Hamada, H. (2007).

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.

Development 134, 3893-3904.

Miyamoto, S., Yagi, H., Yotsumoto, F., Horiuchi, S., Yoshizato, T., Kawarabayashi, T., Kuroki, M. and Mekada, E. (2007).

New approach to cancer therapy: heparin binding-epidermal growth factor-like growth factor as a novel targeting molecule.

Anticancer Res. 27(6A), 3713-3721.

Minami, S., Iwamoto, R. and Mekada, E. (2008).  
HB-EGF decelerates cell proliferation synergistically with TGF-alpha in perinatal distal lung development. 
Dev. Dyn. 237, 247-258.PickOutArticles/entori/2007/12/1_HB-EGFga_chu_sheng_qian_houno_feino_xing_chengni_guan_yushiteirukotowo_mingrakanisuru.html
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PubMedhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11005258&ordinalpos=44&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
PubMedhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11235900&ordinalpos=41&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
PubMedhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10959080&ordinalpos=46&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Yu, X., Miyamoto, S., and Mekada, E. (2000).

Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites.

J. Cell Sci. 113, 2139-2147.

PubMedhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=10825287&ordinalpos=49&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Yotsumoto, F., Yagi, H., Suzuki, SO., Oki, E., Tsujioka, H., Hachisuga, T., Sonoda, K., Kawarabayashi, T., Mekada, E., and Miyamoto, S. (2007).

Validation of HB-EGF and amphiregulin as targets for human cancer therapy.

Biochem. Biophys. Res. Commun. 365, 555-561.

PubMedhttp://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=18023415&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Miyamoto, S., Yagi, H., Yotsumoto, F., Kawarabayashi, T., and Mekada E. (2008).

Heparin-binding epidermal growth factor-like growth factor as a new target molecule for cancer thrapy.

Adv. Exp. Med. Biol. 622, 281-295.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18546636?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Takeda, Y., He, P., Tachibana, I., Zhou, B., Miyado, K., Kaneko, H., Suzuki, M., Minami, S., Iwasaki, T., Goya, S., Kijima, T., Kumagai, T., Yoshida, M., Osaki, T., Komori, T., Mekada, E., and Kawase, I. (2008).

Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes COPD-like phenotype in mice.

J. Biol. Chem. 283, 26089-26097.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18662991?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Miyado, K., Yoshida, K., Yamagata, K., Sakakibara, K., Okabe, M., Wang, X., Miyamoto, K., Akutsu, H., Kondo, T., Takahashi, Y., Ban, T., Ito, C., Toshimori, K., Nakamura, A., Ito, M., Miyado, M., Mekada, E., and Umezawa, A. (2008).

The fusing activity of sperm is bestowed by CD9-containing vesicles released from eggs in mice.

Proc. Natl. Acad. Sci. USA. 105, 12921-12926.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/18728192?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Yagi, H.,  Yotsumoto,  F., Sonoda, K., Kuroki, M., Mekada, E., and, Miyamoto, S. (2009).

Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer.

Int. J. Cancer. 283, 26089-26097.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19048624?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Mekada, E. and Iwamoto, R. (2008).

HB-EGF.

UCSD-Nature Molecule Pages. doi: 10.1038/mp.a002932.01.

Naturehttp://www.signaling-gateway.org/molecule/query?afcsid=A002932
Mizushima, H., Wang, X., Miyamoto, S., and Mekada, E. (2009).
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.
J.Cell Sci. 122, 4277-4286.PickOutArticles/entori/2009/9/12_zeng_zhi_yin_zi.html
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19887590?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

Ichise, T., Adachi, S., Ohishi, M., Ikawa, M., Okabe, M., Iwamoto, R., and Mekada, E. (2010).

Humanized gene replacement in mice reveals the contribution of cancer stroma-derived HB-EGF to tumor growth.

Cell Struct. Funct. 35, 3-13.

(本論文は日本細胞生物学会 CSF Awardを受賞しました)

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20190463

Hamaoka, M., Chinen, I., Murata, T., Takashima, S., Iwamoto, R., and Mekada, E. (2010).

Anti-human HB-EGF monoclonal antibodies inhibiting ectodomain shedding of HB-EGF and diphtheria toxin binding.

J. Biochem. 148, 55-69.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20332144
Iwamoto, R., Mine, N., Kawaguchi, T., Minami, S., Saeki, K., and Mekada, E. (2010).
HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans.
Development 137, 2205-2214.PickOutArticles/entori/2010/5/5_xin_zang_bian_xing_cheng_guo_chengnioiteHB-EGFga_zheng_changni_ji_nengsurutamenihaheparan_liu_suanpuroteogurikantono_xiang_hu_zuo_yongga_bi_xudearukotowo_mingrakanisuru.html
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20530548

Koshikawa, N., Mizushima, H., Minegishi, T., Iwamoto, R., Mekada, E., and Seiki, M.  (2010).

Membrane type I-matrix metalloproteinase cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin-independent growth factor.

Cancer Res. 70, 6093-6103.

PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/20587521