〜論文・総説のリスト〜
Publications (before 2000)

Iwamoto, R., Handa, K. and Mekada, E. (1999)

Contact-dependent Growth Inhibition and Apoptosis of EGF Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor.

J. Biol. Chem. 274, 25906-25912.

Izumi, Y., Hirata, M., Hasuwa, H., Iwamoto, R., Umata, T., Miyado, K., Tamai, Y., Kurisaki, T., Sehara-Fujisawa, A., Ohno, S. and Mekada, E. (1998)

A metalloprotease-disintegrin, MDC9/Meltrin-gamma/ADAM9, and PKC-delta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

EMBO J. 17: 7260-7272.

Umata, T. and Mekada, E. (1998)

Diphtheria toxin translocation across endosome membrane. A novel cell permeabilization assay reveals new diphtheria toxin fragments in endocytic vesicles.

J. Biol. Chem. 273, 8351-8359.

Tsuneoka, M. and Mekada, E. (1998)

N-myc transactivates RCC1 gene expression in rat fibroblast cells transformed by N-myc and v-ras.

J. Biochem. 124, 1013-1019.

Mitamura, T., Umata, T., Nakano, F., Shishido, Y., Toyoda, T., Itai, A., Kimura, H. and Mekada, E. (1997)

Structure-function analysis of the diphtheria toxin receptor toxin binding site by site-directed mutagenesis.

J. Biol. Chem. 272, 27084-27090.

Tsuneoka, M., Nakano, F., Ohgusu, H. and Mekada, E. (1997)

c-myc activates RCC1 gene expression through E-box elements.

Oncogene 14, 2301-2311.

Kagawa, T., Mekada, E., Shishido, Y. and Ikenaka K. (1997)

Immune system-related CD9 is expressed in mouse CNS myelin at very late stage of myelination.

J. Neurosci. Res. 50, 312-320.

Nakagawa, T., Higashiyama, S., Mitamura, T., Mekada, E. and Taniguchi, N. (1996)

Amino-terminal processing of cell surface haparin-binding EGF-like growth factor upregulates its juxtacrine but not its paracrine growth factor activity.

J. Biol. Chem. 271, 30858-30863.

Nakamura, Y., Iwamoto, R. and Mekada, E. (1996)

Expression and distribition of CD9 in myelin of the central and peripheral nervous systems.

Am. J. Pathol. 149, 575-583.

Nakamura,K., Iwamoto,R. and Mekada,E. (1995)

Membrane anchored heparin-binding EGF-like growth factor and DRAP27/CD9 form a complex with integrin alpha3beta1 at cell-cell contact sites.

J. Cell Biol. 129, 1691-1705.

Higashiyama,S., Iwamoto,R., Goishi,K. Raab,G., Taniguchi,N., Klagsbrun,M. and Mekada,E. (1995)

The membrane protein CD9/DRAP27 potentiates the growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor (HB-EGF).

J. Cell Biol. 128,929-938.

Goishi,K., Higashiyama,S., Klagsbrun,M., Nakano,N., Umata,T., Ishikawa,M., Mekada,E. and Taniguchi,N. (1995)

Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor; Conversion from juxtacrine to paracrine growth factor activity.

Mol. Biol. Cell 6, 967-980.

Shishido,Y., Sharma,K.D., Higashiyama,S., Klagsbrun,M. and Mekada, E. (1995)

Heparin-like molecules on the cell surface potentiate binding of diphtheria toxin to the diphtheria toxin receptor/membrane-anchored heparin-binding EGF-like growth factor.

J. Biol. Chem. 270, 29578-29585.

Mitamura,T., Higashiyama,S., Taniguchi,N., Klagsbrun,M. and Mekada,E. (1995)

Diphtheria toxin binds to the EGF-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

J. Biol. Chem. 270, 1015-1019.

Iwamoto,R., Higashiyama,S., Mitamura,T., Taniguchi,N., Klagsbrun,M. and Mekada,E. (1994)

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

EMBO J. 13, 2322-2330.

Tsuneoka,M. Nakayama,K., Hatsuzawa,K., Komada,M., Kitamura,N. and Mekada,E. (1993)

Evidence for involvement of furin in cleavage and activation of diphtheria toxin.

J. Biol. Chem 268, 26461-26465.

Koda,Y., Kimura,H. and Mekada,E. (1993)

Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals.

Blood 82:2915-2919.

Mitamura,T., Iwamoto,R., Umata,T., Yomo,T., Urabe,I., Tsuneoka,M. and Mekada,E. (1992)

The 27-kD diphtheria toxin receptor-associated protein (DRAP27) from Vero cells is the monkey homologue of human CD9 antigen: Expression of DRAP27 elevates the number of diphtheria toxin receptors on toxin-sensitive cells.

J. Cell Biol. 118:1389-1399.

Tsuneoka,M. and Mekada,E. (1992)

Degradation of a nuclear-localized protein in mammalian COS cells using Escerichia coli beta-galactosidase as a model protein.

J. Biol. Chem 267:9107-9111.

Mekada,E., Senoh,H., Iwamoto,R., Okada,Y., and Uchida,T. (1991)

Purification of diphtheria toxin receptor from Vero cells.

J. Biol. Chem. 266:20457-20462.

Iwamoto,R., Senoh,H., Okada,Y., Uchida,T. and Mekada,E. (1991)

An antibody that inhibits the binding of diphtheria toxin to cells, revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor.

J. Biol. Chem. 266:20463-20469.

Umata,T., Moriyama,Y.,Futai,M. and Mekada,E. (1990)

The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H+-ATPase.

J. Biol. Chem. 265:21940-21945.

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